52P Affordable cancer research for under-resourced settings to implement precision medicine: The tale of the Moroccan OVANORDEST-1 study

Research on ovarian cancer (OC) is considerably neglected in Morocco. OVANORDEST (“OVAire dans le NORD-EST” (ovarian North-East of Morocco)) a three-steps research project that aims to develop clinical this aggressive women's for the first time This abstract biomarker analysis affordable predictive and prognostic biomarkers based systemic inflammatory response previously described hallmarks cancer. includes lymphocyte monocyte (LMR), neutrophil (NLR), platelet ratios (PLR) as available under-resourced settings predict outcomes OC. We have appraised all meta-analyses investigated value these three overall survival using an umbrella systematic review (El Bairi et al. Front Oncol, 2021; PROSPERO: CRD42020201493). further developed real-world cohort OC patients at Mohammed VI University Hospital during period 2005-2020. ROC (receiver operating characteristic) Cox regression models were used study impact selected biomarkers. retrospective enrolled 250 cases histologically confirmed epithelial with data used. On univariable analysis, LMR, NLR, PLR associated (p <0.001). which was multivariable analysis. In fact, LMR>3 had higher median (mOS) (31 vs. 23 months) (HR= 1.62; 95% CI: 1.00-2.6; p = 0.04) those NLR<1.6 also superior mOS (50 20 2.04; 1.25-3.35; 0.0043). Similarly, <134.2 favourable (49 vs.21 months; HR= 1.66; 1.07-2.58; 0.02). These encouraging results peripheral immune OS supportive OVANORDEST-2 will validate findings prospective nomogram.